Patents

Cizzle aims to maximise protection of its discoveries in a timely and effective manner and in as many countries of the world as are appropriate to each case.

Cizzle has a number of patent applications in prosecution which relate to  CIZ1, CIZ1 variants and their potential in the prognosis, diagnosis and therapy of a variety of cancer types.

All background IP prior to Cizzle's formation and relevant to its business has been assigned to the Company by the University of York, the University of Cambridge, Cancer Research UK, Yorkshire Cancer Research and the Lister Institute of Preventive Medicine.

Publications

Relevant publications on the function of Ciz1 and its interaction partners

Cloning and characterization of a novel p21(Cip1/Waf1)-interacting zinc finger protein, ciz1. (1999) Mitsui K, Matsumoto A, Ohtsuka S, Ohtsubo M, Yoshimura A. Biochem Biophys Res Commun. 264(2):457-64. PMID: 10529385

Ciz1 promotes mammalian DNA replication. (2005) Coverley D, Marr J, Ainscough J. J Cell Sci. 118:101-12. PMID: 15585571

Distinct roles for cyclins E and A during DNA replication complex assembly and activation. (2002) Coverley D, Laman H, Laskey RA. Nat Cell Biol. 4(7):523-8.  PMID: 12080347

C-terminal domains deliver the DNA replication factor Ciz1 to the nuclear matrix.
Ainscough JF, Rahman FA, Sercombe H, Sedo A, Gerlach B, Coverley D. (2007) J Cell Sci. 120:115-24. PMID: 17182902

Ciz1 cooperates with cyclin A/CDK2 to activate mammalian DNA replication in vitro. (2010) Copeland NA, Sercombe HE, Ainscough J F-X, Coverley D. Journal of Cell Science (in press).

Ciz1 and cancer

Ciz1, a Novel DNA-binding coactivator of the estrogen receptor alpha, confers hypersensitivity to estrogen action. (2006) den Hollander P, Rayala SK, Coverley D, Kumar R. Cancer Res. 2006 66(22):11021-9. PMID: 17108141

Cancer-associated missplicing of exon 4 influences the subnuclear distribution of the DNA replication factor CIZ1. (2007) Rahman FA, Ainscough JF, Copeland N, Coverley D.Hum Mutat. 28(10):993-1004. PMID: 17508423

Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach. (2008) Thalappilly S, Suliman M, Gayet O, Soubeyran P, Hermant A, Lecine P, Iovanna JL, Dusetti NJ. Proteomics. 2008 8(15):3071-81. PMID: 18654987

Ciz1, Cip1 interacting zinc finger protein 1 binds the consensus DNA sequence ARYSR(0-2)YYAC. (2003) Warder DE, Keherly MJ. J Biomed Sci.10(4):406-17. PMID: 12824700

Ciz1, a p21 cip1/Waf1-interacting zinc finger protein and DNA replication factor, is a novel molecular partner for human enhancer of rudimentary homolog. Lukasik A, Uniewicz KA, Kulis M, Kozlowski P. (2008) FEBS J. 275(2):332-40. PMID: 18081865

Differential detection of alternatively spliced variants of Ciz1 in normal and cancer cells using a custom exon–junction microarray (2010) Rahman FA, Aziz N and Coverley D. BMC Cancer (submitted).

Uncoupled expression of the nuclear matrix-associated DNA replication factor Ciz1 in common solid tumours  Sercombe HE, Higgins G, Munkley J, Copeland N, Rahman FA, Ainscough JF-X, Coverley D. (unpublished)

Selective suppression of Ciz1 splice variant expression inhibits small cell lung cancer cell proliferation in vitro and in vivo Roper KM, Higgins G, Rahman F, Watson I, Ainscough JF-X, Coverley D. (Unpublished)

Ciz1 regulation

Glucocorticoid receptor activation of the Ciz1-Lcn2 locus by long range interactions. (2009) Hakim O, John S, Ling JQ, Biddie SC, Hoffman AR, Hager GL. J Biol Chem. 284(10):6048-52. PMID: 19124469

Altered splicing in exon 8 of the DNA replication factor CIZ1 affects subnuclear distribution and is associated with Alzheimer's disease. (2008) Dahmcke CM, Büchmann-Møller S, Jensen NA, Mitchelmore C.Mol Cell Neurosci. 2008 38(4):589-94. PMID: 18583151

Cizzle Biotech
Heslington Hall, Heslington, York, North Yorkshire, Y010 5DD
UK company 5249093